Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition


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Heida, T. and Marani, E. (2010) Dissociated neurons from an extended rat subthalamic area - spontaneous activity and acetylcholine addition. In: XII Mediterranean Conference on Medical and Biological Engineering and Computing, 27-30 May, Chalkidiki, Greece.

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Abstract:The tegmental nucleus pedunculopontinus proves to connect by acetylcholine neurotransmitters, among others, the subthalamic nucleus. Dissociated cultures of the subthalamic nucleus on micro-electrode arrays were studied by addition of acetylcholine and by stimulation. Addition of acetylcholine had no effect on bursting activity, reduced spike activity strongly for a short period, after which activity increased again, but overall activity was reduced over time with 25%. After termination of acetylcholine addition the activity returned to normal.
Item Type:Conference or Workshop Item
Copyright:© 2010 Springer
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/72538
Official URL:http://dx.doi.org/10.1007/978-3-642-13039-7_45
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