Dynamic Combinatorial Libraries Based on Hydrogen-Bonded Molecular Boxes


Kerckhoffs, Jessica M.C.A. and Mateos-Timoneda, Miguel A. and Reinhoudt, David N. and Crego-Calama, Mercedes (2007) Dynamic Combinatorial Libraries Based on Hydrogen-Bonded Molecular Boxes. Chemistry: a European Journal, 13 (8). pp. 2377-2385. ISSN 0947-6539

[img] PDF
Restricted to UT campus only
: Request a copy
Abstract:This article describes two different types of dynamic combinatorial libraries of host and guest molecules. The first part of this article describes the encapsulation of alizarin trimer 2 a3 by dynamic mixtures of up to twenty different self-assembled molecular receptors together with the amplification and selection of the best binder. Receptors (1 a-d)3(DEB)6 are formed by the self-assembly of six diethyl barbiturate (DEB) and calix[4]arene dimelamine derivatives 1 a-d by using hydrogen bonds. The largest amplification factor (2.8) for a host assembly (1 a3 (DEB)6) was observed after the addition of 2 a to four-component library 1 an1 b(3-n)(DEB)6 (n=0-3). Addition of 2 a to twenty-component library 1 an1 bm1 co1 d(3-(n+m+o))(DEB)6 (n, m, o=0-3; (n+m+o)3) also showed amplification of receptor 1 a3(DEB)6. The second part of this article describes the complexation of libraries of different alizarin-like guest molecules (2 a-d) and the self-assembled receptor 1 a3(DEB)6. This receptor is able to template the formation of the best-fitting guest trimer.
Item Type:Article
Copyright:© 2007 Wiley InterScience
Research Group:
Link to this item:http://purl.utwente.nl/publications/72332
Official URL:https://doi.org/10.1002/chem.200601198
Dataset URL:http://www.wiley-vch.de/contents/jc_2111/2007/f601198_s.pdf
Export this item as:BibTeX
HTML Citation
Reference Manager


Repository Staff Only: item control page

Metis ID: 241413