Effect of ghrelin on the network development and activity in cultured cortical neurons of newborn rats


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Stoyanova, Irina and Feber le, Joost and Rutten, Wim (2010) Effect of ghrelin on the network development and activity in cultured cortical neurons of newborn rats. In: 7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA Meeting 2010, 29 June-2 July 2010, Reutlingen, Germany.

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Abstract:Ghrelin is a gastric hormone and a neuropeptide, initially related to the appetite stimulation and growth hormone secretation. Ghrelin has also an important role in regulation of many other processes, including higher brain funtions like memory performance, sleep and wakefulness. Previous studies on the ghrelin activities indicate that the transmitter has an excitatory effect on the neuronal activity of hypothalamic slices in vitro by direct synaptic interaction, and controls synaptic plasticity in the hippocampus when applied intravenously. However the effect of ghrelin on developing neuronal networks has not been studied yet. Therefore we cultured dissociated cortical neurons of newborn rats in a medium containing ghrelin for a period of three weeks and recorded the network activity using multy electrod arrays,.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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