Liquid Chromatography with On-Line Electrochemical Derivatization and Fluorescence Detection for the Determination of Phenols

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Meyer, Jörg and Liesener, André and Götz, Sebastian and Hayen, Heiko and Karst, Uwe (2003) Liquid Chromatography with On-Line Electrochemical Derivatization and Fluorescence Detection for the Determination of Phenols. Analytical Chemistry, 75 (4). pp. 922-926. ISSN 0003-2700

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Abstract:A new methodological approach for the determination of monosubstituted phenols is described. After liquid chromatographic separation of the analytes, an on-line electrochemical derivatization is carried out and the reaction products are detected fluorometrically. Phenols are oxidized in the electrochemical cell to form fluorescent dimers and higher oligomers, which were identified by on-line electrochemistry/mass spectrometry. Major advantages of the proposed method include enhanced selectivity and sensitivity. Without prior enrichment of the analytes, limits of detection down to 2 × 10-9 M (20 fmol) may be reached for selected phenols, e.g., for 4-octylphenol, 4-ethylphenol, and 4-(1-indanyl)phenol. Only readily available instrumentation is required for these measurements.
Item Type:Article
Copyright:© 2003 American Chemical Society
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Link to this item:http://purl.utwente.nl/publications/72268
Official URL:http://dx.doi.org/10.1021/ac0204808
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Metis ID: 216429