Molecular Printboards as a General Platform for Protein Immobilization: A Supramolecular Solution to Nonspecific Adsorption

Ludden, Manon J.W. and Mulder, Alart and Tampe, Robert and Reinhoudt, David N. and Huskens, Jurriaan (2007) Molecular Printboards as a General Platform for Protein Immobilization: A Supramolecular Solution to Nonspecific Adsorption. Angewandte Chemie, International Edition in English, 46 (22). pp. 4104-4107. ISSN 0570-0833

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Abstract:	Be specific: A supramolecular adsorbate consisting of an adamantyl group (red) and an oligo(ethylene glycol) chain has been designed to prevent nonspecific protein adsorption at cyclodextrin molecular printboards. The adamantyl group allows specific and reversible interactions. Specific immobilization of proteins (gray) is possible through multivalent orthogonal linkers by effective replacement of the monovalent adsorbate (Ni2+ ions (green) may be needed; see picture).
Item Type:	Article
Copyright:	© 2007 Wiley InterScience
Faculty:	Science and Technology (TNW)
Research Group:	Molecular Nanofabrication (MNF)
Link to this item:	http://purl.utwente.nl/publications/72203
Official URL:	http://dx.doi.org/10.1002/anie.200605104
Dataset URL:	http://www.wiley-vch.de/contents/jc_2002/2007/z605104_s.pdf
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