Influence of process parameters on extraction equilibria for the chiral separation of amines and amino-alcohols with a chiral crown ether

Share/Save/Bookmark

Steensma, Maartje and Kuipers, Norbert J.M. and Haan de, André B. and Kwant, Gerard (2006) Influence of process parameters on extraction equilibria for the chiral separation of amines and amino-alcohols with a chiral crown ether. Journal of Chemical Technology and Biotechnology, 81 (4). pp. 588-597. ISSN 0268-2575

[img]PDF
Restricted to UT campus only
: Request a copy
155Kb
Abstract:Reactive extraction is studied as a promising chiral separation technique for commercial production scale. For chiral separation of amines and amino alcohols, a chiral crown ether was identified as a versatile enantioselective extractant. In this paper, the influence of various process conditions on the extraction performance is studied experimentally, and a predictive model is constructed based on the chemical and physical equilibria. It was found that the operational selectivity in one extraction step is mainly determined by the complexation constants between crown ether and enantiomers (which are dependent on solvent and temperature) and by the extractant concentration, whereas the distribution ratio is also strongly influenced by the pH. The model gives an excellent prediction of the operational selectivity and a good explanation for the system's responses to changes in process conditions. The model can be used as a basis for a multistage equilibrium extractor model and for conceptual process design. Under optimal process conditions, an operational selectivity >1.5 was obtained for five out of seven model compounds, with satisfying distribution ratios (D ~ 1-10).
Item Type:Article
Copyright:© 2006 Wiley InterScience
Research Group:
Link to this item:http://purl.utwente.nl/publications/72192
Official URL:http://dx.doi.org/10.1002/jctb.1434
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 235433