Stereocomplex Mediated Gelation of PEG-(PLA)2 and PEG-(PLA)8 Block Copolymers


Hiemstra, Christine and Zhong, Zhiyuan and Dijkstra, Pieter J. and Feijen, Jan (2005) Stereocomplex Mediated Gelation of PEG-(PLA)2 and PEG-(PLA)8 Block Copolymers. Macromolecular Symposia, 224 (1). pp. 119-132. ISSN 1022-1360

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Abstract:Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.
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Copyright:© 2005 Wiley InterScience
Science and Technology (TNW)
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Metis ID: 224367