The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size

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Zweers, Miechel L.T. and Grijpma, Dirk W. and Engbers, Gerard H.M. and Feijen, Jan (2003) The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size. Journal of Biomedical Materials Research. Part B: Applied biomaterials, 66 (2). pp. 559-566. ISSN 0021-9304

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Abstract:In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.
Item Type:Article
Copyright:© 2002 Wiley InterScience
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71910
Official URL:http://dx.doi.org/10.1002/jbm.b.10046
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