Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers

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Zhong, Zhiyuan and Dijkstra, Pieter J. and Feijen, Jan and Kwon, Young-Min and Bae, You Han and Kim, Sung Wan (2002) Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers. Macromolecular Chemistry and Physics, 203 (12). pp. 1797-1803. ISSN 1022-1352

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Abstract:Novel biodegradable thermosensitive triblock copolymers of poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) (PMG-PEG-PMG) have been synthesized. Ring-opening polymerization of D,L-3-methyl-glycolide (MG) initiated with poly(ethylene glycol) (PEG) and Ca[N(SiMe3)2]2(THF)2 provided triblock copolymers with alternating lactyl/glycolyl sequences of controlled molecular weight, low polydispersity index and uniform chain structure. At relatively low temperatures (≈10 °C) these copolymers formed clear solutions in water up to high concentrations (50 wt.-%). Depending on molecular mass ratios of PMG and PEG blocks, a sol-gel transition or an increase in viscosity without gel formation was observed upon increasing the temperature of the aqueous solutions. The temperature-induced gelation was ascertained by rheology and dynamic differential scanning calorimetry (DDSC).
Item Type:Article
Copyright:© 2002 Wiley InterScience
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71846
Official URL:http://dx.doi.org/10.1002/1521-3935(200208)203:12<1797::AID-MACP1797>3.0.CO;2-A
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