Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

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Patil, Chetan A. and Bosschaart, Nienke and Keller, Matthew D. and Leeuwen, Ton G. van and Mahadevan-Jansen, Anita (2008) Combined Raman spectroscopy and optical coherence tomography device for tissue characterization. Optics Letters, 33 (10). pp. 1135-1137. ISSN 0146-9592

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Abstract:coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.
Item Type:Article
Copyright:© 2008 Optical Society of America
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71716
Official URL:http://dx.doi.org/10.1364/OL.33.001135
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