Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy

Bosschaart, Nienke and Aalders, Maurice C. and Faber, Dirk J. and Weda, Jelmer J. and Gemert van, Martin J.C. and Leeuwen van, Ton G. (2009) Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy. Optics Letters, 34 (23). pp. 3746-3748. ISSN 0146-9592

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Abstract:	Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (µa) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455–680 nm wavelength range with a spectral resolution of 8 nmto obtain µa spectra with ±0.5 mm−1 accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations.
Item Type:	Article
Copyright:	© 2009 Optical Society of America
Faculty:	Science and Technology (TNW)
Research Group:	Biomedical Photonic Imaging (BMPI)
Link to this item:	http://purl.utwente.nl/publications/71715
Official URL:	http://dx.doi.org/10.1364/OL.34.003746
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Metis ID: 261716