Crosslinking of porcine aortic leaflets with butane-1,4-diol diglycidyl ether


Dijkstra, Pieter J. and Zeeman, Raymond and Feijen, Jan (2001) Crosslinking of porcine aortic leaflets with butane-1,4-diol diglycidyl ether. Macromolecular Symposia, 172 (1). pp. 11-20. ISSN 1022-1360

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Abstract:Currently, efforts are being made to reduce xenograft calcification and to optimize biomechanical properties by applying different crosslinking methods and techniques. Porcine aortic leaflets could be stabilized with a bisepoxy compound, butane-1,4-diol diglycidyl ether (BDDGE), under acidic (pH 4.5) or alkaline conditions (pH > 8.5). Maximum values of the shrinkage temperature (83°C), which are comparable to glutaraldehyde-crosslinked materials, are achieved at pH 9.0 and 10.0 within 48 h with a BDDGE concentration of 4 wt6percnt;. The crosslinking efficacy decreased at higher pH values or at prolonged reaction times due to a higher proportion of one-side or masking reactions. Crosslinking of aortic leaflets at pH 4.5, which consisted in a reaction between the epoxide groups of BDDGE and the carboxylic acid groups of the tissue, afforded crosslinked material with a shrinkage temperature of 76°C after 7 days of reaction.
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Copyright:© 2001 Wiley InterScience
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