Polyethylene glycol-grafted polystyrene particles


Meng, Fenghua and Engbers, Gerard H.M. and Feijen, Jan (2004) Polyethylene glycol-grafted polystyrene particles. Journal of Biomedical Materials Research. Part A, 70A (1). pp. 49-58. ISSN 1549-3296

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Abstract:Densely pegylated particles that can serve as a model system for artificial cells were prepared by covalently grafting amino polyethylene glycol (PEG, molecular weight 3400 or 5000) onto carboxyl polystyrene particles (PS-COOH) using carbodiimide chemistry. PEG-modified particles (PS-PEG) were characterized by determination of the PEG surface concentration, -potential, size, and morphology. Under optimized grafting conditions, a dense brush-like PEG layer was formed. A PEG surface concentration of approximately 60 pmol/cm2, corresponding with an average distance between grafted PEG chains of 17 Å can be realized. It was shown that grafting of PEG onto PS-COOH reduced the adsorption of proteins from human plasma (85 vol %) in phosphate-buffered saline up to 90%
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71380
Official URL:https://doi.org/10.1002/jbm.a.30056
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