Liquid chromatographic–mass spectrometric studies on the in vitro degradation of a poly(ether ester) block copolymer

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Hayen, Heiko and Deschamps, Audrey A. and Grijpma, Dirk W. and Feijen, Jan and Karst, Uwe (2004) Liquid chromatographic–mass spectrometric studies on the in vitro degradation of a poly(ether ester) block copolymer. Journal of Chromatography A, 1029 (1-2). pp. 29-36. ISSN 0021-9673

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Abstract:A detailed study on the in vitro degradation of a poly(ethylene glycol) and poly(butylene terephthalate) (PEOT/PBT) segmented block copolymer was carried out using liquid chromatography/electrospray–mass spectrometry. Accelerated hydrolysis of PEOT/PBT was achieved by placing the material for 14 days in a refluxing phosphate buffered saline (pH 7.4) solution. All major degradation products and several side-products were identified using both the positive and the negative ion mode. The data indicate that degradation does not only occur in the “soft”, but also in the “hard” segments of the polymer. Liquid chromatographic separation is required to distinguish between degradation products with different sequences but identical molecular mass. The addition of ammonium and sodium ions provided important complementary information on the number of monomer units present in the degradation products.
Item Type:Article
Copyright:© 2004 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71375
Official URL:http://dx.doi.org/10.1016/j.chroma.2003.12.056
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