Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy

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Zhang, Zheng and Zou, Shan and Vancso, Julius and Grijpma, Dirk W. and Feijen, Jan (2005) Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy. Biomacromolecules, 6 (6). pp. 3404-3409. ISSN 1525-7797

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Abstract:In this article, the surface erosion of spin-coated poly(trimethylene carbonate) (PTMC) films by lipase solutions from Thermomyces lanuginosus was studied using atomic force microscopy (AFM). PTMC films (23−48 nm thick) were stable in water at 37 °C for 16 h, while after immersion in lipase solutions at 37 °C for 30 s and 1 min, the average thickness of the film decreased in time at a rate of 11.0 ± 3.7 nm/min. The initially smooth films became significantly rougher during the erosion process. When the immersion time of the films in the lipase solutions was limited to less than 5 s, degradation of the surface was minimal and individual lipase molecules adsorbed on PTMC films could be discerned. By microcontact printing of the PTMC surfaces using a patterned PDMS stamp and lipase solution for 30 s, a predefined micropattern consisting of parallel, 5-μm-wide lines lying 5-nm deep and separated at a distance of 2 μm was formed. Friction images showed differences in surface properties between the recessed and protruding lines in the pattern.
Item Type:Article
Copyright:ACS
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71338
Official URL:http://dx.doi.org/10.1021/bm050460q
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