Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy

Zhang, Zheng and Zou, Shan and Vancso, Julius and Grijpma, Dirk W. and Feijen, Jan (2005) Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy. Biomacromolecules, 6 (6). pp. 3404-3409. ISSN 1525-7797

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Abstract:	In this article, the surface erosion of spin-coated poly(trimethylene carbonate) (PTMC) films by lipase solutions from Thermomyces lanuginosus was studied using atomic force microscopy (AFM). PTMC films (23−48 nm thick) were stable in water at 37 °C for 16 h, while after immersion in lipase solutions at 37 °C for 30 s and 1 min, the average thickness of the film decreased in time at a rate of 11.0 ± 3.7 nm/min. The initially smooth films became significantly rougher during the erosion process. When the immersion time of the films in the lipase solutions was limited to less than 5 s, degradation of the surface was minimal and individual lipase molecules adsorbed on PTMC films could be discerned. By microcontact printing of the PTMC surfaces using a patterned PDMS stamp and lipase solution for 30 s, a predefined micropattern consisting of parallel, 5-μm-wide lines lying 5-nm deep and separated at a distance of 2 μm was formed. Friction images showed differences in surface properties between the recessed and protruding lines in the pattern.
Item Type:	Article
Copyright:	ACS
Faculty:	Science and Technology (TNW)
Research Group:	Materials Science and Technology of Polymers (MTP) Biomaterials Science and Technology (BST) Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/71338
Official URL:	http://dx.doi.org/10.1021/bm050460q
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