Water-soluble cationic poly(ferrocenylsilane): An efficient DNA condensation and transfection agent

Zhong, Z.Y. and Lin, C. and Ma, Y. and Hempenius, M.A. and Lok, M.C. and Fretz, M.M. and Engbersen, J.F.J. and Vancso, G.J. and Hennink, W.E. and Feijen, J. (2006) Water-soluble cationic poly(ferrocenylsilane): An efficient DNA condensation and transfection agent. Journal of Controlled Release, 116 (2). e81-e83. ISSN 0168-3659

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Abstract:	The DNA condensation and in vitro gene transfer properties of an organo-iron polymer, cationic poly(ferrocenylsilane), were investigated. Gel retardation assay, dynamic light scattering (DLS), atomic force microscopy (AFM) and zeta-potential measurements showed that cationic poly(ferrocenylsilane) is able to condense plasmid DNA into positively charged nano-sized particles at N/P ratios ≥ 2/1. These polyplexes displayed low cytotoxicity and were able to efficiently transfect COS-7 cells. Keywords: poly(ferrocenylsilane), plasmid DNA, polyplexes, gene delivery
Item Type:	Article
Copyright:	Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Biomolecular Nanotechnology (BNT) Materials Science and Technology of Polymers (MTP) Biomedical Chemistry (BMC) Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/71118
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2006.09.061
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