Water-soluble cationic poly(ferrocenylsilane): An efficient DNA condensation and transfection agent

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Zhong, Z.Y. and Lin, C. and Ma, Y. and Hempenius, M.A. and Lok, M.C. and Fretz, M.M. and Engbersen, J.F.J. and Vancso, G.J. and Hennink, W.E. and Feijen, J. (2006) Water-soluble cationic poly(ferrocenylsilane): An efficient DNA condensation and transfection agent. Journal of Controlled Release, 116 (2). e81-e83. ISSN 0168-3659

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Abstract:The DNA condensation and in vitro gene transfer properties of an organo-iron polymer, cationic poly(ferrocenylsilane), were investigated. Gel retardation assay, dynamic light scattering (DLS), atomic force microscopy (AFM) and zeta-potential measurements showed that cationic poly(ferrocenylsilane) is able to condense plasmid DNA into positively charged nano-sized particles at N/P ratios ≥ 2/1. These polyplexes displayed low cytotoxicity and were able to efficiently transfect COS-7 cells.

Keywords: poly(ferrocenylsilane), plasmid DNA, polyplexes, gene delivery
Item Type:Article
Additional information:Proceedings of the Ninth European Symposium on Controlled Drug Delivery
Copyright:Elsevier
Faculty:
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/71118
Official URL:http://dx.doi.org/10.1016/j.jconrel.2006.09.061
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Metis ID: 236898