Trimethylene carbonate-based polymers for controlled drug delivery applications

Zhang, Z. and Grijpma, D.W. and Feijen, J. (2006) Trimethylene carbonate-based polymers for controlled drug delivery applications. Journal of Controlled Release, 116 (2). e28-e29. ISSN 0168-3659

PDF
Restricted to UT campus only: Request a copy
123Kb

Abstract:	Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days
Item Type:	Article
Copyright:	Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Biomaterials Science and Technology (BST) Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/71117
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2006.09.032
Export this item as:	BibTeX EndNote HTML Citation Reference Manager

Show download statistics for this publication

Repository Staff Only: item control page

Metis ID: 245517