Trimethylene carbonate-based polymers for controlled drug delivery applications


Zhang, Z. and Grijpma, D.W. and Feijen, J. (2006) Trimethylene carbonate-based polymers for controlled drug delivery applications. Journal of Controlled Release, 116 (2). e28-e29. ISSN 0168-3659

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Abstract:Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days
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Additional information:Proceedings of the Ninth European Symposium on Controlled Drug Delivery
Science and Technology (TNW)
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Metis ID: 245517