Disulfide-containing poly(β-amino ester)s for gene delivery

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Lin, C. and Lammens, T.M. and Zhong, Z.Y. and Gu, H. and Lok, M.C. and Jiang, X. and Hennink, W.E. and Feijen, J. and Engbersen, J.F.J. (2006) Disulfide-containing poly(β-amino ester)s for gene delivery. Journal of Controlled Release, 116 (2). e79-e81. ISSN 0168-3659

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Abstract:A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.
Item Type:Article
Additional information:Proceedings of the Ninth European Symposium on Controlled Drug Delivery
Copyright:Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71108
Official URL:http://dx.doi.org/10.1016/j.jconrel.2006.09.060
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Metis ID: 236897