Disulfide-containing poly(β-amino ester)s for gene delivery


Lin, C. and Lammens, T.M. and Zhong, Z.Y. and Gu, H. and Lok, M.C. and Jiang, X. and Hennink, W.E. and Feijen, J. and Engbersen, J.F.J. (2006) Disulfide-containing poly(β-amino ester)s for gene delivery. Journal of Controlled Release, 116 (2). e79-e81. ISSN 0168-3659

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Abstract:A group of new disulfide-containing poly(β-amino ester)s was synthesized and evaluated as non-viral gene delivery vectors. These linear polymers were obtained by Michael addition of a number of selected amines to bis(2-acryloyloxyethyl) disulfide. It was shown that the disulfide-containing poly(β-amino ester)s can condense plasmid DNA into nanoscaled and positively charged polyplexes, which could be rapidly destabilized in an intracellular reductive environment. Polyplexes of the polymer of histamine and bis(2-acryloyloxyethyl) disulfide show efficient transfection of COS-7 cells along with a relatively low cytotoxicity.
Item Type:Article
Additional information:Proceedings of the Ninth European Symposium on Controlled Drug Delivery
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/71108
Official URL:http://dx.doi.org/10.1016/j.jconrel.2006.09.060
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