Three-dimensional Mach-Zehnder interferometer in a microfluidic chip for spatially-resolved label-free detection

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Crespi, Andrea and Gu, Yu and Ngamson, Bongkot and Hoekstra, Hugo J.W.M. and Dongre, Chaitanya and Pollnau, Markus and Ramponi, Roberta and Vlekkert van den, Hans H. and Watts, Paul and Cerullo, Giulio and Osellame, Roberto (2010) Three-dimensional Mach-Zehnder interferometer in a microfluidic chip for spatially-resolved label-free detection. Lab on a Chip, 10 (9). pp. 1167-1173. ISSN 1473-0197

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Abstract:Ultrafast laser writing of waveguides in glasses is a very flexible and simple method for direct on-chip integration of photonic devices. In this work we present a monolithic optofluidic device in fused silica providing label-free and spatially-resolved sensing in a microfluidic channel. A Mach-Zehnder interferometer is inscribed with the sensing arm orthogonally crossing the microfluidic channel and the reference arm passing over it. The interferometer is integrated either with a microchannel fabricated by femtosecond laser technology or into a commercial lab-on-chip for capillary electrophoresis. The device layout, made possible by the unique three-dimensional capabilities of the technique, enables label-free sensing of samples flowing in the microchannel with spatial resolution of about 10 um and limit of detection down to 10e-4 RIU.
Item Type:Article
Copyright:© 2010 Royal Society of Chemistry
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/70977
Official URL:http://dx.doi.org/10.1039/b920062b
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