The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia

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Terstappen, L.W.M.M. and Grooth, B.G. de and Berkel, W. van and Napel, C.H.H. ten and Reijn, M. van and Greve, J. (1988) The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia. European Journal of Haematology, 41 (5). pp. 496-505. ISSN 0902-4441

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Abstract:We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL). Using specific cellular characteristics we could distinguish normal from abnormal cells. The irradiation resulted in a decrease of lymph node size, reduction in spleen volume and decrease in peripheral blood lymphocytes. The one exception was a patient with a prolymphocytoid transformation of B-CLL. For 3 patients SI had to be interrupted or stopped because of severe cytopenia. Quantitation of malignant B cells and normal T lymphocytes revealed that the total irradiation dose which resulted in a specific decrease of malignant lymphocytes varied from patient to patient. Normal T-cell subpopulations, which were increased before SI, decreased to normal or abnormally low values during SI. In previously untreated patients, natural killer (NK) cell numbers decreased more rapidly than T-cell subpopulations. For 2 patients refractory to chemotherapy an increase of NK cells was observed upon SI.
Item Type:Article
Copyright:© 1988 Wiley InterScience
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/70836
Official URL:http://dx.doi.org/10.1111/j.1600-0609.1988.tb00233.x
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