Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters

Marck, K.W. and Wildevuur, Ch.R.H. and Sederel, W.L. and Bantjes, A. and Feijen, J. (1977) Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters. Journal of Biomedical Materials Research, 11 (3). pp. 405-422. ISSN 0021-9304

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Abstract:	A series of copoly(α-amino acids) with varying percentages of hydrophilic (l-aspartic acid) and hydrophobic monomers (l-leucine, ß-methyl-l-aspartate, and ß-benzyl-l-aspartate) were implanted subcutaneously in rats and the macroscopic degradation behavior was studied. Three groups of materials (A, B, C) with different ranges of hydrophilicity were distinguished: A) hydrophobic materials showed no degradation after 12 weeks; B) more hydrophilic materials revealed a gradual reduction in size of the samples, but were still present after 12 weeks; and C) hydrophilic copolymers disappeared within 24 hr. The tissue reactions caused by the materials of group A resembled that of silicone rubber, whereas those of group B showed a more cellular reaction.
Item Type:	Article
Copyright:	© 1977 Wiley InterScience
Faculty:	Science and Technology (TNW)
Research Group:	Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/70741
Official URL:	http://dx.doi.org/10.1002/jbm.820110308
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