Crosslinked agarose encapsulated sorbents resistant to steam sterilization. Preparation and mechanical properties

Koning de, Henk W.M. and Chamuleau, Rob A.F.M. and Bantjes, Adriaan (1983) Crosslinked agarose encapsulated sorbents resistant to steam sterilization. Preparation and mechanical properties. Journal of Biomedical Materials Research, 18 (1). pp. 1-13. ISSN 0021-9304

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Abstract:	The application of agarose in hemoperfusion is hampered by the lack of a suitable sterilization method. A technique has been developed for the crosslinking of agarose encapsulated sorbents by the reaction with 1,3-dichloro-2-propanol (DCP) under strong alkaline conditions. A twofold molar excess of DCP with respect to agarose and an equimolar amount of sodium hydroxide at a concentration of 0.3 mol/L with a reaction time of 1-4 h at 50°C are found to be the optimal conditions. The compressive strength of crosslinked beads is increased by a factor of 4. Agarose capsules are found to degrade by the influence of Y radiation, but are resistant to steam sterilization at 134°C during at least 30 min when crosslinked.
Item Type:	Article
Copyright:	© 1983 Wiley InterScience
Link to this item:	http://purl.utwente.nl/publications/70739
Official URL:	http://dx.doi.org/10.1002/jbm.820180103
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