Synthetic heparinoids labelled with 125I and 35S


Sederel, L.C. and Kolar, Z. and Does, L. van der and Bantjes, A. (1982) Synthetic heparinoids labelled with 125I and 35S. Journal of Labelled Compounds and Radiopharmaceuticals, 19 (10). pp. 1251-1263. ISSN 0362-4803

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Abstract:The labelling of a water-soluble synthetic polyelectrolyte, having anticoagulant activity, has been studied. The polyelectrolyte is derived from cis-1,4-polyisoprene and contains N-sulfate and carboxylate groups. [125I]-Iodination of the polyelectrolyte, using the Chloramine-T method and an electrolytic method, resulted in a [125I]-labelled polyelectrolyte from which release of the label occurred. Resulfation of a partially desulfated polyelectrolyte with a [35S]-sulfur trioxide trimethylamine complex resulted in a [35S]-labelled polyelectrolyte which showed no release of the label.
Item Type:Article
Copyright:© 1982 Wiley InterScience
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