Synthetic heparinoids labelled with 125I and 35S

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Sederel, L.C. and Kolar, Z. and Does van der, L. and Bantjes, A. (1982) Synthetic heparinoids labelled with 125I and 35S. Journal of Labelled Compounds and Radiopharmaceuticals, 19 (10). pp. 1251-1263. ISSN 0362-4803

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Abstract:The labelling of a water-soluble synthetic polyelectrolyte, having anticoagulant activity, has been studied. The polyelectrolyte is derived from cis-1,4-polyisoprene and contains N-sulfate and carboxylate groups. [125I]-Iodination of the polyelectrolyte, using the Chloramine-T method and an electrolytic method, resulted in a [125I]-labelled polyelectrolyte from which release of the label occurred. Resulfation of a partially desulfated polyelectrolyte with a [35S]-sulfur trioxide trimethylamine complex resulted in a [35S]-labelled polyelectrolyte which showed no release of the label.
Item Type:Article
Copyright:© 1982 Wiley InterScience
Link to this item:http://purl.utwente.nl/publications/70711
Official URL:http://dx.doi.org/10.1002/jlcr.2580191015
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