Problems in Treating Experimentally Induced Acute Hepatic Failure by Hemoperfusion or Cross Circulation

Chamuleau, Robert A.F.M. and Popken, Robert J. and Beyerbacht, Ellen C. and Koning de, Henk W.M. (1983) Problems in Treating Experimentally Induced Acute Hepatic Failure by Hemoperfusion or Cross Circulation. Hepatology, 3 (5). pp. 696-700. ISSN 0270-9139

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Abstract:	Acute hepatic failure was induced in rats by galactosamine injection intraperitoneally (1 gm per kg). Twenty-four hours later rats were treated by hemoperfusion (HP) over encapsulated sorbents: cellulose acetate-coated charcoal, polyelectrolyte-coated XAD4, a combination of both, or cross circulation with a healthy donor. Compared with control treatment (prevention of hypoglycemia by glucose infusion), the survival rate was not improved by HP or cross circulation: controls 19% vs. treated animals 0 to 17%. Extension of duration or increased frequency of HP gave the same survival rates. Computer simulation based on zero-order introduction of a possible toxin into a two-compartment model shows that HP up to 5 hr per day is not able to clear the body effectively from the assumed toxin if its partition coefficient exceeds a value of 50.
Item Type:	Article
Copyright:	© 1983 Wiley InterScience
Link to this item:	http://purl.utwente.nl/publications/70693
Official URL:	http://dx.doi.org/10.1002/hep.1840030512
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