The pedunculopontine nucleus as alternative target for deep brain stimulation


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Lourens, M.A.J. and Meijer, H.G.E. and Heida, T. and Gils van, S.A. (2009) The pedunculopontine nucleus as alternative target for deep brain stimulation. In: Annual Symposium of the IEEE-EMBS Benelux Chapter 2009, 9-10 November 2009, Enschede, the Netherlands.

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Abstract:Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment.
The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2].
Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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