The pedunculopontine nucleus as alternative target for deep brain stimulation


Lourens, M.A.J. and Meijer, H.G.E. and Heida, T. and Gils, S.A. van (2009) The pedunculopontine nucleus as alternative target for deep brain stimulation. In: Annual Symposium of the IEEE-EMBS Benelux Chapter 2009, 9-10 November 2009, Enschede, the Netherlands (pp. p. 27).

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Abstract:Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment.
The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2].
Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
Item Type:Conference or Workshop Item
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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