Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry

Terstappen, L.W.M.M. and Grooth de, B.G. and Berkel van, W. and Napel ten, C.H.H. (1988) Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry. Leukemia Research, 12 (7). pp. 551-557. ISSN 0145-2126

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Abstract:	We studied the occurrence of T-cell subpopulations for patients with B-cell chronic lymphocytic leukemia. The CD8+ population was divided into CD8+ suppressor (CD8a+) and CD8+ cytotoxic (CD8b+) lymphocytes using difference in orthogonal light scattering. Average CD4+/CD8+ratios determined for all patients were decreased. For individual patients this sometimes was not true. In contrast CD4+/CD8a+ ratios were markedly increased in all individual patients. The CD8+ lymphocytes appeared to consist mainly of CD8b+lymphocytes. Moreover the CD8b+/CD8+ ratio correlated with clinical stage: untreated patients (stage 0 of Rai) have smaller CD8b+/CD8+ ratios than patients with advanced stages of Rai.
Item Type:	Article
Copyright:	© 1988 Elsevier Science
Faculty:	Science and Technology (TNW)
Research Group:	Medical Cell BioPhysics (MCBP)
Link to this item:	http://purl.utwente.nl/publications/70288
Official URL:	http://dx.doi.org/10.1016/0145-2126(88)90084-7
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