Synihesis of 3-substituied indoles via a modified madeling reaction


Orlemans, E.O.M. and Schreuder, A.H. and Conti, P.G.M. and Verboom, W. and Reinhoudt, D.N. (1987) Synihesis of 3-substituied indoles via a modified madeling reaction. Tetrahedron, 43 (16). pp. 3817-3826. ISSN 0040-4020

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Abstract:Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt -Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1_H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.
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Copyright:© 1987 Elsevier Science
Science and Technology (TNW)
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