Biodegradable polymersomes for controlled drug release

Zhou, W. and Feijen, J. (2008) Biodegradable polymersomes for controlled drug release. Journal of Controlled Release, 132 (3). e35-e36. ISSN 0168-3659

PDF
Restricted to UT campus only: Request a copy
120Kb

Abstract:	Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.
Item Type:	Article
Copyright:	Elsevier B.V.
Faculty:	Science and Technology (TNW)
Research Group:	Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/69433
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2008.09.022
Export this item as:	BibTeX EndNote HTML Citation Reference Manager

Show download statistics for this publication

Repository Staff Only: item control page

Metis ID: 254630