Biodegradable polymersomes for controlled drug release

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Zhou, W. and Feijen, J. (2008) Biodegradable polymersomes for controlled drug release. Journal of Controlled Release, 132 (3). e35-e36. ISSN 0168-3659

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Abstract:Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.
Item Type:Article
Copyright:Elsevier B.V.
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/69433
Official URL:http://dx.doi.org/10.1016/j.jconrel.2008.09.022
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