Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach

Rivron, N.C. and Le Gac, S. and Vrij, E. and Rouwkema, J. and Wijnperle, D. and Truckenmuller, R. and Berg van den, A. and Blitterswijk van, C.A. (2009) Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. In: MicroTAS 2009, Thirteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, 1-5 Nov 2009, Jeju, Korea.

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Abstract:	Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.
Item Type:	Conference or Workshop Item
Faculty:	Science and Technology (TNW) Electrical Engineering, Mathematics and Computer Science (EEMCS) Engineering Technology (CTW)
Research Group:	Tissue Regeneration (TR) Biomedical and Environmental Sensor systems (BIOS) Biomechanical Engineering (BE)
Link to this item:	http://purl.utwente.nl/publications/69347
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