Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach


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Rivron, N.C. and Le Gac, S. and Vrij, E. and Rouwkema, J. and Wijnperle, D. and Truckenmuller, R. and Berg, A. van den and Blitterswijk, C.A. van (2009) Microfabrication of shaped MM-scale tissues to study vascular development using modular bottom-up approach. In: MicroTAS 2009, Thirteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, 1-5 Nov 2009, Jeju, Korea (pp. pp. 9-11).

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Abstract:Recapitulating developmental mechanisms in vitro necessitate models of intermediate complexity, between simple 2D culture and complex in vivo models, which integrate both physical and molecular cues. Here, we describe a cheap and simple bottom-up microfabrication method to build 3D millimeter-scale tissues with geometric shapes. These tissues are suitable for long-term culture in tissue-based assays and as implants for clinical applications. In a case study, we recapitulate some mechanisms of vasculogenesis, the assembly of capillary blood vessels.
Item Type:Conference or Workshop Item
Faculty:
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Engineering Technology (CTW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/69347
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