Preparation of porous poly(trimethylene carbonate) structures for controlled release applications using high pressure CO2

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Nalawade, S.P. and Westerman, D. and Leeke, G. and Santos, R.C.D. and Grijpma, D.W. and Feijen, J. (2008) Preparation of porous poly(trimethylene carbonate) structures for controlled release applications using high pressure CO2. Journal of Controlled Release, 132 (3). e73-e75. ISSN 0168-3659

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Abstract:Porous poly(trimethylene carbonate) structures can readily be prepared using high pressure CO2. Differences in CO2 solubility in the polymer matrix at the different processing temperatures and pressures lead to different pore morphologies upon depressurization. Furthermore, crystallization of the initially amorphous polymer leads to stable porous structures. This variation in pore structure can be used to tailor polymer matrix degradation rates and drug release profiles
Item Type:Article
Copyright:© 2008 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/69318
Official URL:http://dx.doi.org/10.1016/j.jconrel.2008.09.067
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