A microfluidic device for monitoring siRNA delivery under fluid flow

Meer van der, A.D. and Kamphuis, M.M.J. and Poot, A.A. and Feijen, J. and Vermes, I. (2008) A microfluidic device for monitoring siRNA delivery under fluid flow. Journal of Controlled Release, 132 (3). e42-e44. ISSN 0168-3659

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Abstract:	When studying particle uptake in vitro, it is favorable to mimic the in vivo situation as much as possible. In this study we present a microfluidic device to mimic the mechanical stress caused by the flow of blood while studying particle uptake in vitro. Human endothelial cells were treated with liposomes containing fluorescent siRNA. It was found that applying physiologically relevant mechanical stress during transfection diminishes the uptake of liposomes in the cells.
Item Type:	Article
Copyright:	Elsevier B.V.
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS) Science and Technology (TNW)
Research Group:	Biomedical and Environmental Sensor systems (BIOS) Biomaterials Science and Technology (BST) Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/69301
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2008.09.028
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