Hyperbranched poly(amidoamine)s containing disulfide linkages in the main chain for DNA transfection

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Martello, F. and Engbersen, J.F.J. and Ferruti, P. (2008) Hyperbranched poly(amidoamine)s containing disulfide linkages in the main chain for DNA transfection. Journal of Controlled Release, 132 (3). e10-e12. ISSN 0168-3659

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Abstract:Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.
Item Type:Article
Copyright:Elsevier B.V.
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/69298
Official URL:http://dx.doi.org/10.1016/j.jconrel.2008.09.046
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