Hyperbranched poly(amidoamine)s containing disulfide linkages in the main chain for DNA transfection

Martello, F. and Engbersen, J.F.J. and Ferruti, P. (2008) Hyperbranched poly(amidoamine)s containing disulfide linkages in the main chain for DNA transfection. Journal of Controlled Release, 132 (3). e10-e12. ISSN 0168-3659

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Abstract:	Two different hyperbranched poly(amidoamine)s (PAAs) were prepared by hydrogen-transfer polyaddition of N,N′-bisacryloylcystamine (CBA) with ethylenediamine (EDA) and of N,N′-bisacryloylpiperazine (BAP) with cystamine. Remarkable results were obtained in the DNA complexation tests, including particle size and zeta-potential measurement. Since the cationic structure of these polymers should permit an easier penetration of DNA through the cell membrane and the presence of the disulfide linkages should ensure a reductive degradation of the polymer main chain inside cells, these polymers can be regarded as promising vectors for an efficient gene delivery.
Item Type:	Article
Copyright:	Elsevier B.V.
Faculty:	Science and Technology (TNW)
Research Group:	Biomedical Chemistry (BMC)
Link to this item:	http://purl.utwente.nl/publications/69298
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2008.09.046
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