The double dipole model of theta rhythm generation: Simulation of laminar field potential profiles in dorsal hippocampus of the rat

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Holsheimer, J. and Boer, J. and Lopes da Silva, F.H. and Rotterdam, A. van (1982) The double dipole model of theta rhythm generation: Simulation of laminar field potential profiles in dorsal hippocampus of the rat. Brain research, 235 (1). pp. 31-50. ISSN 0006-8993

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Abstract:A set of compartmental models of CA1 pyramidal, granular and polymorph cells of the dorsal hippocampus have been used to simulate membrane potentials generated by synaptic activation at various levels along these cells. From the membrane potential distributions the field potentials in dorsal CA1 and the dorsal blade of the dentate area have been simulated using a model based on volume conduction theory. Field potential profiles similar to laminar profiles, found experimentally in the dorsal hippocampus during theta rhythm, could only be simulated by assuming (almost) simultaneous synaptic excitation of the 3 cell types at given sites. The results lead to 2 alternative models for the simultaneous excitation of CA1 pyramidal cells and dentate granular cells during theta rhythm. Other electrophysiological evidence favours the model in which the two neuronal populations are activated distally near the fissure.
Item Type:Article
Copyright:© 1982 Elsevier Science
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Link to this item:http://purl.utwente.nl/publications/69000
Official URL:http://dx.doi.org/10.1016/0006-8993(82)90194-9
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