Development of biodegradable poly(amidoamine)s for protein delivery


Coué, G. and Feijen, J. and Engbersen, J.F.J. (2008) Development of biodegradable poly(amidoamine)s for protein delivery. Journal of Controlled Release, 132 (3). e2-e3. ISSN 0168-3659

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Abstract:Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.
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Copyright:© 2008 Elsevier
Science and Technology (TNW)
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