Application of direct fluid flow oscillations to improve mixing in microbioreactors


Li, X. and Steen, G. van der and Dedem, G.W.K. van and Wielen, L.A.A. van der and Gulik, W.M. van and Heijnen, J.J. and Ottens, M. and Krommenhoek, E.E. and Gardeniers, J.G.E. and Berg, A. van den (2009) Application of direct fluid flow oscillations to improve mixing in microbioreactors. AIChE journal, 55 (10). pp. 2725-2736. ISSN 0001-1541

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Abstract:This article describes an active mixing method for a microbioreactor that was designed, simulated, tested, and successfully implemented. By applying a varying pressure to a microchannel looping tangentially into a cylindrical microreactor an oscillating fluid flow was shown to occur. Such an oscillating fluid flow improved mixing, both by diffusion and convection. The oscillating fluid flow has a large impact on the ratio between the diffusion domain and the convection domain. A good match was obtained between experimental mixing results, computational fluid dynamics simulation results and the results of a simplified mixing model thus demonstrating the potential of simulation on improving the design of microreactors. (C) 2009 American Institute of Chemical Engineers AIChE J, 55: 2725-2736, 2009
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Copyright:© 2009 American Institute of Chemical Engineers
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