Electrophoretic separation of DNA in gels and nanostructures

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Salieb-Beugelaar, G.B. and Dorfman, K.D. and Berg, A. van den and Eijkel, J.C.T. (2009) Electrophoretic separation of DNA in gels and nanostructures. Lab on a Chip, 9 (17). pp. 2508-2523. ISSN 1473-0197

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Abstract:The development of nanostructure devices has opened the door to new DNA separation techniques and fundamental investigations. With advanced nanotechnologies, artificial gels (e.g. nanopillar arrays, nanofilters) can be manufactured with controlled and ordered geometries. This contrast with gels, where the pores are disordered and the range of available pore sizes is limited by the level of cross-linking and the mechanical properties of the gel. In this review, we recall the theories developed for free-solution and gel electrophoresis (extended Ogston model, biased reptation and entropic trapping) and from this perspective, suggestions for future concepts for fast DNA separation using nanostructures will be given.
Item Type:Article
Copyright:© 2009 Royal Society of Chemistry
Faculty:
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/68304
Official URL:http://dx.doi.org/10.1039/b905448k
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