Preparation of Degradable Porous Structures Based on 1,3-Trimethylene Carbonate and D,L-Lactide (Co)polymers for Heart Tissue Engineering

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Pego, A.P. and Siebum, B. and Luyn van, M.J.A. and Gallego y Van Seijen, X.J. and Poot, A.A. and Grijpma, D.W. and Feijen, J. (2003) Preparation of Degradable Porous Structures Based on 1,3-Trimethylene Carbonate and D,L-Lactide (Co)polymers for Heart Tissue Engineering. Tissue Engineering, 9 (5). pp. 981-994. ISSN 1076-3279

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Abstract:Biodegradable porous scaffolds for heart tissue engineering were prepared from amorphous elastomeric (co)polymers of 1,3-trimethylene carbonate (TMC) and D,L-lactide (DLLA). Leaching of salt from compression-molded polymer-salt composites allowed the preparation of highly porous structures in a reproducible fashion. By adjusting the salt particle size and the polymer-to-particle weight ratio in the polymer-salt composite preparation the pore size and porosity of the scaffolds could be precisely controlled. The thermal properties of the polymers used for scaffold preparation had a strong effect on the morphology, mechanical properties and dimensional stability of the scaffolds under physiological conditions. Interconnected highly porous structures (porosity, 94%; average pore size, 100 μm) based on a TMC-DLLA copolymer (19:81, mol%) had suitable mechanical properties and displayed adequate cell-material interactions to serve as scaffolds for cardiac cells. This copolymer is noncytotoxic and allows the adhesion and proliferation of cardiomyocytes. During incubation in phosphate-buffered saline at 37°C, these scaffolds were dimensionally stable and the number average molecular weight (Mn) of the polymer decreased gradually from 2.0 × 105 to 0.3 × 105 in a period up to 4 months. The first signs of mass loss (5%) were detected after 4 months of incubation. The degradation behavior of the porous structures was similar to that of nonporous films with similar composition and can be described by autocatalyzed bulk hydrolysis.
Item Type:Article
Copyright:© 2003 Mary Ann Liebert
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/67194
Official URL:http://dx.doi.org/10.1089/107632703322495628
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