Neural growth into a microchannel network: towards a regenerative neural interface

Wieringa, Paul A. and Wiertz, Remy W.F. and Feber le, Joost and Rutten, Wim L.C. (2009) Neural growth into a microchannel network: towards a regenerative neural interface. In: 4th International IEEE EMBS Conference on Neural Engineering, 29 April - 2 May 2009, Antalya, Turkey.

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Abstract:	We propose and validated a design for a highly selective 'endcap' regenerative neural interface towards a neuroprosthesis. In vitro studies using rat cortical neurons determine if a branching microchannel structure can counter fasciculated growth and cause neurites to separte from one another, allowing for greater selective contact. Initial studies find that narrower branching microchannels achieve improved neurite separation. Electical stimulation of neurites within michrochannels is possible, as is recording of neurite action potentials with the microchannels acting as electrical singal amplifiers.
Item Type:	Conference or Workshop Item
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Biomedical Signals and Systems (BSS)
Link to this item:	http://purl.utwente.nl/publications/65493
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