Fluorescence monitoring of capilarry electrophoresis separation in a lab-on-a-chip with monolithically integrated waveguides


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Dongre, C. and Dekker, R. and Hoekstra, H.J.W.M. and Martinez-Vazquez, R. and Osellame, R. and Ramponi, R. and Cerullo, G. and Weeghel, R. van and Besselink, G.A.J. and Vlekkert, H.H. van den and Pollnau, M. (2008) Fluorescence monitoring of capilarry electrophoresis separation in a lab-on-a-chip with monolithically integrated waveguides. In: 13th Annual Symposium of the IEEE LEOS Benelux Chapter, 27-28 November 2008, Enschede, The Netherlands (pp. pp. 159-162).

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Abstract:Femtosecond-laser-written optical waveguides were monolithically integrated into a commercial lab-on-a-chip to intersect a microfluidic channel. Laser excitation through these waveguides confines the excitation window to a width of 12 μm, enabling high-spatial-resolution monitoring of different fluorescent analytes, during their migration/separation in the microfluidic channel by capillary electrophoresis. Wavelength-selective monitoring of the on-chip separation of fluorescent dyes is implemented as a proof-of-principle. We envision well-controlled microfluidic plug formation, waveguide excitation, and a low limit of detection to enable monitoring of extremely small quantities with high spatial resolution.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/65281
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