Ultra-rapid separation of an angiotensin mixture in nanochannels using shear-driven chromatography

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Vankrunkelsven, Sarah and Clicq, David and Cabooter, Deidre and De Malsche, Wim and Gardeniers, J.G.E. and Desmet, Gert (2006) Ultra-rapid separation of an angiotensin mixture in nanochannels using shear-driven chromatography. Journal of Chromatography A, 1102 (1-2). pp. 96-103. ISSN 0021-9673

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Abstract:The present paper reports on the separation of a mixture of fluorescein isothiocyanate-labeled angiotensin I and II peptides in a shear-driven nanochannel with a C-18-coating and using an eluent consisting of 5% acetonitrile in 0.02 M aqueous phosphate buffer at pH 6.5. The flat-rectangular nanochannel in fused silica consisted of an etched structure in combination with a flat moving wall. The very fast separation kinetics that can be achieved in a nanochannel allowed to separate the angiotensin peptides in less then 0.2 s in a distance of only 1.8 mm. Plate heights as small as 0.4 mu m were calculated after substraction of the injection effect. (c) 2006 Elsevier B.V. All rights reserved.
Item Type:Article
Copyright:© 2006 Elsevier
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/63736
Official URL:http://dx.doi.org/10.1016/j.chroma.2005.10.017
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