On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetic particles in continuous flow

Pamme, Nicole and Eijkel, Jan C.T. and Manz, Andreas (2006) On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetic particles in continuous flow. Journal of Magnetism and Magnetic Materials, 307 (2). pp. 237-244. ISSN 0304-8853

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Abstract:	The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.
Item Type:	Article
Copyright:	© 2006 Elsevier
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Biomedical and Environmental Sensor systems (BIOS)
Link to this item:	http://purl.utwente.nl/publications/63732
Official URL:	http://dx.doi.org/10.1016/j.jmmm.2006.04.008
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Metis ID: 237674