Ghrelin expression in dissociated cultures, of the rat neocortex


Stoyanova, Irina I. and Wiertz, Remy W.F. and Rutten, Wim L.C. (2009) Ghrelin expression in dissociated cultures, of the rat neocortex. In: 4th International IEEE EMBS Conference on Neural Engineering, 29 April - 2 May 2009, Antalya, Turkey (pp. pp. 159-162).

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Abstract:Ghrelin is a hormone, initially described as a gastric peptide stimulating appetite and growth hormone secretrion, which also has an important role in the regulation of many other processes including higher brain functions. Ghrelin has been described in situ in different part of the brain, but so far there are no data about it in cell cultures. Therefore, we aimed this study in order to investigate the developmental pattern of ghrelin in dissociated cortical neurons. We applied the ABC immunocytochemical mehtod for detection of ghrelin in dissociated cortical neurons from newborn rats, incubated for one day, one week, or two weeks. Our results clearly show that at the early stages of development of the network all the neurons are ghrelin-positive and their number decreases along the incubation period. As ghrelin is so omnipresent in the early stages, it may also influence the early development of synaptic formation and cell-to-cell interactions, both very important for the network functions like learning and memory.
Item Type:Conference or Workshop Item
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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