Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics


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Li, J. and Le Gac, S. and Berg, A. van den (2008) Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. In: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTas 2008, 12-16 October 2008, San Diego, CA, USA (pp. pp. 1236-1238).

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Abstract:We show that both the post pattern and arrangement have an influence on the
cell movement (zigzag vs. bump mode) in deterministic hydrodynamics while the
current theory is limited to one parameter, the array row shift ε for cylindrical posts. Besides, a new mechanism of cell movement, the “stair movement” mechanism is reported; thereby, cells are laterally shifted across stream lines in a laminar flow. Our new designs greatly shorten the separation length (~1 mm vs. ~20 cm) for fractionating cells compared to previous works [1], and consequently the separation time, and alleviate any cell clogging problem.
Item Type:Conference or Workshop Item
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/62719
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