Microfluidic apoptosis chip for drug screening to improve and personalize cancer therapy


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Wolbers, F. and Franke, H.R. and Andersson-Svahn, S.M.H. and Vermes, I. and Berg, A. van den (2008) Microfluidic apoptosis chip for drug screening to improve and personalize cancer therapy. In: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 12-16 Oct 2008, San Diego, California (pp. pp. 549-551).

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Abstract:Currently, the knowledge on breast cancer treatment is increasing, however, there are still hardly any assays present to match patients to the right form of therapy to enhance the therapeutic effectiveness. Therefore a microfluidic device is developed to analyze the hormonal and chemosensitivity of first breast cancer cell lines (MCF-7) and in a later stage a patients’ own tumor cells. The apoptotic inducers tumor ne-crosis factor-α, in combination with cycloheximide, and staurosporine stained MCF-7 cells positive for Annexin V and PI, and showed a decrease in area coverage as compared to untreated cells.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/62715
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