Improving mixing in microbioreactors


Li, X. and Steen, G. van der and Dedum, G.W.K. and Wielen, L.A.M. van der and Leeuwen, M. van and Gulik, W.M. van and Heijnen, J.J. and Krommenhoek, E.E. and Gardeniers, J.G.E. and Berg, A. van den and Ottens, M. (2008) Improving mixing in microbioreactors. Chemical Engineering Science, 63 (11). pp. 3036-3046. ISSN 0009-2509

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Abstract:This paper describes a possible active mixing method for a 30 mu l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior. (C) 2008 Elsevier Ltd. All rights reserved.
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Copyright:© 2008 Elsevier
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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