Sonoporation of suspension cells in a microfluidic format by use of a single cavitation bubble.


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Le Gac, S. and Berg, A. van den and Ohl, C.D. (2007) Sonoporation of suspension cells in a microfluidic format by use of a single cavitation bubble. In: Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences - The proceedings of microTAS 2007 Conference, 7-11 october 2007, Paris (pp. pp. 206-209).

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Abstract: We report here on both viable and permanent poration of (suspension) cells by combining microfluidics and cavitation bubbles. Cells are placed in a PDMS microchamber and exposed to a single 100-μm sized cavitation bubble. The expansion and collapse of the bubble results in shear on cells, and eventually thereby in cellular poration. We demonstrate that cell poration depends on the initial cell-bubble distance and we determine a critical distance below which > 50 % cells are affected by the bubble.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/62036
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