Cardiac responses of vagus nerve stimulation: Intraoperative bradycardia and subsequent chronic stimulation

Ardesch, J.J. and Buschman, H.P.J. and Burgh van der, P.H. and Wagener-Schimmel, L.J. and Aa van der, H.E. and Hageman, G. (2007) Cardiac responses of vagus nerve stimulation: Intraoperative bradycardia and subsequent chronic stimulation. Clinical Neurology and Neurosurgery, 109 (10). pp. 849-852. ISSN 0303-8467

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Abstract:	OBJECTIVES: Few adverse events on heart rate have been reported with vagus nerve stimulation (VNS) for refractory epilepsy. We describe three cases with intraoperative bradycardia during device testing. PATIENTS AND METHODS: At our hospital 111 patients have received a VNS system. Intraoperative device testing is performed under ECG-monitoring. We reviewed the patients and their VNS-therapy follow-up outcome who experienced a change in heart rate, during device testing (Lead Test). RESULTS: Three patients with medically refractory epilepsy showed a bradycardia during intraoperative Lead Test. Postoperative the VNS-therapy started under ECG-monitoring. No change in cardiac rhythm occurred. Subsequent chronic stimulation is uneventful. All three have reduced seizure frequency. Two already have had their second implant, without the occurrence of bradycardia. CONCLUSION: In case of intraoperative bradycardia VNS-therapy onset should be done under ECG-monitoring. Subsequent chronic stimulation is safe in respect to heart rate. Bradycardia during intraoperative device testing is no reason to abort the operation.
Item Type:	Article
Copyright:	© 2007 Elsevier
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Biomedical Signals and Systems (BSS)
Link to this item:	http://purl.utwente.nl/publications/61944
Official URL:	http://dx.doi.org/10.1016/j.clineuro.2007.07.024
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