Differential effects of bisphosphonates on breast cancer cell lines

Share/Save/Bookmark

Verdijk, R. and Franke, H.R. and Wolbers, F. and Vermes, I. (2007) Differential effects of bisphosphonates on breast cancer cell lines. Cancer Letters, 246 (1-2). pp. 308-312. ISSN 0304-3835

[img]PDF
Restricted to UT campus only
: Request a copy
112Kb
Abstract:Bisphosphonates may induce direct anti-tumor effects in breast cancers cells in virtro. In this study, six bisphosphonates were administered to three breast caner cell lines. Cell proliferation was measured by quantification of th expressio of Cyclin D1 mRNA. Apoptosis was determined by flow cytometry of a DNA fragmentation assay. We demonstrated that bisphosphonates have direct effects on cell proliferation and apoptosis in different breast cander cell lines. However, not all bisphosphonates act equally on breast cancer cells in vitro. Zoledronate seems to be the most potent of the six bisphosphonates. This in vitro study showed that bisphosphonates possess promising anti-tumor potential.
Item Type:Article
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:
Link to this item:http://purl.utwente.nl/publications/61845
Official URL:http://dx.doi.org/10.1016/j.canlet.2006.03.011
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 241781