Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat


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Heida, T. and Usunoff, K.G. and Marani, E. (2007) Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat. In: International Federation for Medical and Biological Engineering Proceedings, 26-30 June 2007, Ljubljana, Slovenia.

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Abstract:Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds.
Item Type:Conference or Workshop Item
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Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/61780
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