Chemoreception by a cell with age-dependent receptor binding sites

Geurts, Bernard J. and Wiegel, Frederik W. (1990) Chemoreception by a cell with age-dependent receptor binding sites. Mathematical Biosciences, 98 (2). pp. 171-183. ISSN 0025-5564

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Abstract:	The authors determine the time-dependent ligand current into a spherical cell that is covered with a large number of age-dependent receptors. These receptor can be either of two states: active (i.e., available for ligand binding) or inactive. An active receptor turns inactive upon binding a ligand, and it can reappear as active at some later time. The transition inactive → active is treated as a probabilistic process. The ligand distribution around the cell is determined analytically in terms of this distribution at the cell surface. A set of nonlinear integral equations is derived for the distribution at the cell surface, which is solved numerically. In this way the time-dependent ligand current into the cell as well as the average active receptor population at the cell surface are determined.
Item Type:	Article
Copyright:	© 1990 Elsevier Science
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Mathematics of Computational Science (MaCS)
Link to this item:	http://purl.utwente.nl/publications/61296
Official URL:	http://dx.doi.org/10.1016/0025-5564(90)90122-F
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